What is the best way to stop taking antidepressants according to new research?

The most effective method involves a slow, gradual tapering of dosage combined with psychological support, as identified by a study in The Lancet Psychiatry.

How much does slow tapering reduce depression relapse risk?

Slow tapering, especially with psychological support, reduces the risk of depression relapse by 48% compared to abrupt stopping.

Which antidepressant discontinuation strategies carry the highest relapse risk?

Abruptly stopping antidepressants or fast tapering without adequate support are associated with the highest risk of relapse.

Home / Health / New Study: Gradual Tapering Cuts Relapse Risk

New Study: Gradual Tapering Cuts Relapse Risk

11 Dec, 2025

•

Summary

Slow tapering with psychological support significantly reduces relapse risk.
Abrupt or fast tapering of antidepressants carries the highest relapse risk.
Gradual withdrawal with support could prevent relapse in one in five individuals.

New Study: Gradual Tapering Cuts Relapse Risk

A groundbreaking study published in The Lancet Psychiatry reveals that the most effective strategy for discontinuing antidepressant medication involves a slow, gradual tapering of dosage alongside psychological support. This method was found to be nearly as effective as continuing the medication, significantly reducing the risk of depression relapse compared to abrupt cessation or rapid tapering, which carry the highest risks. Researchers analyzed data from over 17,300 patients across 76 clinical trials, concluding that updated clinical guidelines should promote individualized deprescribing with gradual tapering and structured psychological support to improve patient outcomes globally.

Disclaimer: This story has been auto-aggregated and auto-summarised by a computer program. This story has not been edited or created by the Feedzop team.