Home / Health / AIIMS-Led Study Explores Why Autoimmune Diseases Run in Families
AIIMS-Led Study Explores Why Autoimmune Diseases Run in Families
29 Oct
Summary
- Study investigates genetic and immune factors in families with autoimmune diseases.
- 200 families with at least three affected members are sought for the research.
- Blood samples will analyze genetic variations and biological markers.
A comprehensive four-year research initiative, supported by the Indian Council of Medical Research (ICMR), is delving into the complex reasons behind the familial clustering of autoimmune diseases. Spearheaded by AIIMS, New Delhi, and collaborating with five other clinical centers, the project seeks to recruit 200 families where at least three members have autoimmune conditions, including systemic lupus erythematosus (SLE).
The study, titled 'Genomic Profiling and Identification of Targetable Shared Immunopathogenic Events in Multiplex Families with Autoimmune Disease,' will collect blood samples from both affected and unaffected family members. This will allow researchers to examine genetic variations, cytokine profiles, and other biological markers.
Dr. Ranjan Gupta of AIIMS highlighted that genetics alone cannot fully explain disease development, suggesting environmental influences and immune response differences play crucial roles. Lupus serves as the primary disease for family eligibility, with other related conditions like myositis or type 1 diabetes also considered.
The findings are anticipated to reveal shared disease mechanisms and potential biomarkers for risk, offering avenues for future therapeutic targets. Recruitment is ongoing across six centers, with an invitation for families in Delhi and surrounding areas to participate.
