What new nanoparticle therapy for Alzheimer's was developed by INST?

INST researchers developed EGCG-dopamine-tryptophan nanoparticles (EDTNPs), later enhanced with BDNF (B-EDTNPs), to treat Alzheimer's by targeting multiple disease aspects simultaneously.

How do green tea nanoparticles help treat Alzheimer's disease?

These nanoparticles integrate EGCG from green tea with other compounds to combat amyloid aggregation, oxidative stress, inflammation, and neuronal degeneration, offering a multi-faceted treatment.

What were the results of the nanoparticle therapy in mouse models?

In mouse models, the nanoparticles successfully disassembled toxic amyloid plaques, reduced brain inflammation, and improved memory and learning capabilities.

Home / Health / Green Tea Nanoparticles Offer New Hope for Alzheimer's

Green Tea Nanoparticles Offer New Hope for Alzheimer's

17 Dec

•

Summary

New nanoparticles combine green tea, neurotransmitter, and amino acid.
Therapy simultaneously targets amyloid, oxidative stress, inflammation, and degeneration.
Nanoparticles disassembled plaques and improved memory in mouse models.

Green Tea Nanoparticles Offer New Hope for Alzheimer's

Scientists at the Institute of Nano Science and Technology in Mohali have pioneered a new nanoparticle-based approach for treating Alzheimer's Disease. Unlike conventional therapies that focus on single pathological features, this novel treatment integrates epigallocatechin-3-gallate from green tea, dopamine, and tryptophan into nanoparticles. This combination allows the therapy to simultaneously address four key hallmarks of Alzheimer's: amyloid aggregation, oxidative stress, inflammation, and neuronal degeneration.

The research further enhanced these nanoparticles by incorporating Brain-Derived Neurotrophic Factor (BDNF), creating a dual-action platform. This B-EDTNPs not only clear harmful amyloid-beta aggregates but also promote the regeneration of neurons. This integrated approach, combining antioxidant, anti-amyloid, and neurotrophic actions, represents a significant advancement in Alzheimer's therapeutic strategies.