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Green Tea Nanoparticles Offer New Hope for Alzheimer's
17 Dec, 2025
Summary
- New nanoparticles combine green tea, neurotransmitter, and amino acid.
- Therapy simultaneously targets amyloid, oxidative stress, inflammation, and degeneration.
- Nanoparticles disassembled plaques and improved memory in mouse models.
Scientists at the Institute of Nano Science and Technology in Mohali have pioneered a new nanoparticle-based approach for treating Alzheimer's Disease. Unlike conventional therapies that focus on single pathological features, this novel treatment integrates epigallocatechin-3-gallate from green tea, dopamine, and tryptophan into nanoparticles. This combination allows the therapy to simultaneously address four key hallmarks of Alzheimer's: amyloid aggregation, oxidative stress, inflammation, and neuronal degeneration.
The research further enhanced these nanoparticles by incorporating Brain-Derived Neurotrophic Factor (BDNF), creating a dual-action platform. This B-EDTNPs not only clear harmful amyloid-beta aggregates but also promote the regeneration of neurons. This integrated approach, combining antioxidant, anti-amyloid, and neurotrophic actions, represents a significant advancement in Alzheimer's therapeutic strategies.
Laboratory experiments and studies with mouse models demonstrated the nanoparticles' efficacy. They were observed to disassemble toxic plaques, reduce brain inflammation, restore cellular balance, and notably improve memory and learning functions. Computer simulations corroborated these findings, showing the nanoparticles actively disassembling amyloid-beta fibrils at a molecular level, offering a promising new avenue for Alzheimer's treatment.
