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Eric Dane's Final Role: Battling ALS On Screen
20 Feb
Summary
- Dane portrayed a firefighter with ALS in a final poignant role.
- His performance earned a 10-minute standing ovation from the crew.
- He announced a return to Euphoria and upcoming thriller film.

Actor Eric Dane made a profound final on-screen appearance months before his passing at 53, portraying a firefighter with ALS in the NBC series "Brilliant Minds." The role mirrored his personal battle with the disease, which he revealed in April 2025. Dane's character, Matthew, wrestled with disclosing his diagnosis to his family and accepting help.
His performance in the "Brilliant Minds" episode resonated deeply with fans, drawing emotional reactions and a remarkable 10-minute standing ovation from the production crew. Showrunner Michael Grassi noted Dane's vulnerability and the scene's moving message about accepting care. This appearance was one of Dane's last, with future projects including the final season of HBO's "Euphoria" and the thriller film "Family Secrets."
ALS, or Lou Gehrig's disease, is a progressive motor neuron disorder affecting thousands annually. Dane, diagnosed in April 2025, experienced a swift decline, losing use of his right arm by June. Throughout his health struggle, his ex-wife, Rebecca Gayheart, provided strong support, with the couple having previously halted their divorce proceedings.
Dane's career spanned iconic roles, including Dr. Mark Sloan in "Grey's Anatomy" and Cal Jacobs in "Euphoria." Creator Sam Levinson mourned his loss, calling him a cherished friend and colleague. Dane's final on-screen moments are remembered for their emotional impact and the powerful message of resilience in the face of devastating illness.




