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Applegate's MS Misdiagnosis: Still a Warrior for the Community
27 Oct
Summary
- Christina Applegate was misdiagnosed with MS five years ago.
- She vows to continue advocating for the MS community.
- Applegate experiences worsening symptoms despite not having MS.

Actress Christina Applegate recently disclosed that she was misdiagnosed with multiple sclerosis (MS) five years ago. In a recent podcast episode, Applegate reassured her listeners that she remains dedicated to advocating for those living with the condition. She expressed deep affection for the MS community, calling them "my people" and pledging to continue championing their causes.
Despite no longer having an MS diagnosis, Applegate described experiencing debilitating symptoms that have worsened over time. She detailed significant mobility issues, including difficulty getting out of bed and using a walker, alongside reports of excruciating pain and weakness. These new and intensifying symptoms have led her doctors to investigate the underlying cause since 2021.
A neurology expert confirmed that MS misdiagnoses are relatively common due to the lack of a single definitive diagnostic test. Applegate acknowledged that many other conditions can mimic MS symptoms, prompting a thorough online investigation by her medical team to understand her current health challenges.