Amy Schumer's Shocking 50lb Weight Loss Revealed

Amy Schumer made a striking appearance at the New York City premiere of the documentary film 'Lorne,' showcasing a significant 50lb weight loss. The comedian, 44, revealed that she achieved this transformation using the weight-loss drug Mounjaro. She has openly shared her positive experience with Mounjaro on social media in March 2025, praising it for improving her skin, hair, and energy levels.

Schumer detailed that Mounjaro worked better for her than other medications like Wegovy, which she previously found difficult to tolerate, causing her to experience vomiting. She also mentioned that Ozempic was not suitable for her. The film 'Lorne,' directed by Morgan Neville, is set for an April 17 theatrical release and features interviews with SNL stars.

The premiere also drew attention due to an alleged incident involving Natasha Lyonne. The 'Orange Is The New Black' star was reportedly asked to leave a Delta flight shortly before the event. Lyonne later tweeted about the experience, expressing regret for missing a scheduled appearance on 'The Drew Barrymore Show.' Other notable attendees included SNL cast members Chloe Fineman, Kenan Thompson, and Colin Jost, alongside Lorne Michaels himself.