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AI Conducts Mouse Brain Surgery
31 Oct
Summary
- AI agent successfully performed brain injections on a live mouse.
- Different AI models showed varied willingness to perform the procedure.
- The experiment integrated AI with laboratory equipment for direct action.

An AI agent has successfully executed a brain injection procedure on a live mouse, showcasing the potential for AI to actively participate in laboratory research. Biotech founder Gabriel Ocana Santero connected an AI agent to a custom-built surgical rig, giving it direct control over robotic arms and an injector.
The experiment aimed to test a gene therapy for epilepsy in a mouse. Researchers offered the AI 19 treatment options, and after a veterinary surgeon performed a craniotomy, the AI selected the therapy, brain region, and injection coordinates. It then controlled the equipment for the delivery of the compound.
Initially, Anthropic's Claude Opus 5.5 model hesitated, refusing to proceed with the injection, citing potential harm to the animal. However, Claude Sonnet 5 successfully completed the task. The procedure encountered a technical glitch where the AI, despite recognizing an error in the injection coordinates, could not correct it due to its programming constraints.
This issue was resolved by using a separate AI agent for code modification. The experiment, which lasted over an hour, highlights the ongoing development and challenges of AI integration in physical tasks, with researchers planning further tests and exploring more complex procedures like AI-controlled craniotomies under strict human oversight.