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Rams Edge 49ers in Crucial NFC West Clash
2 Oct
Summary
- Rams and 49ers both 3-1 before Week 5 matchup
- Rams bounce back from Week 3 collapse, 49ers lose at home
- Stafford throws for 375 yards, 3 TDs for Rams

On Thursday, October 3rd, 2025, the Los Angeles Rams and San Francisco 49ers squared off in a crucial NFC West matchup. Both teams entered the game with 3-1 records, setting the stage for an important early-season divisional clash.
The Rams were looking to bounce back after a brutal collapse against the Eagles in Week 3, while the 49ers were aiming to rebound from a home loss to the Jaguars in Week 4. Rams quarterback Matthew Stafford rose to the occasion, throwing for 375 yards and 3 touchdowns on 29-of-41 passing. His standout performance helped the Rams secure a hard-fought victory over their division rivals.
The 49ers, led by quarterback Brock Purdy, put up a valiant effort, but their comeback bid ultimately fell short. Purdy threw for 309 yards, 2 touchdowns, and 2 interceptions, also losing a fumble in the game.
With this win, the Rams have taken control of the NFC West standings, while the 49ers will look to regroup and mount a challenge in the coming weeks.