Wildcats Seek Upset Over Cyclones in Crucial Big 12 Clash

As of September 28th, 2025, the Arizona Wildcats are off to their best start since 2015, having won their first three games by a combined 93 points. However, they now face a significant challenge as they take on the 4-0 Iowa State Cyclones, who are ranked 13th nationally and have already secured a Big 12 Conference victory.

The Wildcats' defense has been stifling so far, ranking 30th nationally in rushing defense and 7th in total defense. Meanwhile, the Cyclones' offense has been productive, averaging 161 yards per game on the ground. This sets up an intriguing clash of styles as the two teams meet on the field.

Adding to the intrigue is the fact that this game marks Iowa State's only home appearance in a seven-week stretch, the longest such period since 1997. The Cyclones will be eager to protect their home turf against the surging Wildcats, who will be looking to pull off the upset and continue their impressive start to the season.