What is the exocyst complex's new role found by JNCASR researchers?

JNCASR researchers discovered that the exocyst complex, previously known for cell surface transport, is crucial for autophagy, the cell's 'self-eating' process.

How can JNCASR's autophagy discovery help with diseases?

The discovery aids in developing therapeutic strategies for diseases like Alzheimer's, Parkinson's, and cancer by understanding a key cellular cleanup mechanism.

What is autophagy and why is it important for cells?

Autophagy is the cell's process of removing damaged materials and defending against infections, vital for maintaining cell health, especially in long-lived neurons.

Home / Science / Cellular 'Self-Eating' Mystery Solved by JNCASR

Cellular 'Self-Eating' Mystery Solved by JNCASR

21 Dec, 2025

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Summary

Exocyst complex, known for cell surface transport, crucial for autophagy.
Discovery aids therapeutic strategies for Alzheimer's, Parkinson's, and cancer.
Yeast cells used to reveal autophagosome formation mechanism.

Cellular 'Self-Eating' Mystery Solved by JNCASR

Scientists at the Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) have revealed a surprising role for the exocyst complex in autophagy, the essential cellular process of waste removal and renewal. This protein group, traditionally known for transporting molecules to the cell surface, is now understood to be vital for forming the 'trash bags' cells use to clear damaged components. This breakthrough offers significant potential for developing new treatments for conditions such as Alzheimer's, Parkinson's disease, and various cancers.

The research, conducted using simple yeast cells, elucidated the mechanism behind autophagosome biogenesis, a key stage in the autophagy pathway. Understanding how this process is regulated is crucial, as disruptions in autophagy are implicated in numerous diseases. The exocyst complex, comprising eight proteins, plays a critical role, with seven of these proteins essential for correctly forming the cellular waste containers.