Weight Loss Jabs: Doctor Warns of 'Miserable' Side Effect

An NHS doctor has identified constipation as a particularly "miserable" and prevalent side effect associated with weight loss injections, commonly known as GLP-1 inhibitors. These medications, including Ozempic, Mounjaro, and Wegovy, are effective for diabetes management and aiding weight loss by slowing gastric emptying. This mechanism, while beneficial for appetite control, also reduces the speed at which the gastrointestinal tract functions, resulting in slower stool passage and increased water absorption, leading to constipation.

The impact of this side effect can vary, with higher doses and pre-existing digestive issues potentially exacerbating the problem. Medical sources indicate that digestive issues like constipation affect up to one in ten individuals using these injections. Other potential side effects include nausea, diarrhea, stomach pain, tiredness, dizziness, hair loss, low blood sugar, and a fast heart rate.

To manage and prevent constipation while using these injections, medical advice emphasizes several lifestyle adjustments. Ensuring adequate hydration is crucial for maintaining soft stools. A daily intake of 30 grams of fiber from fruits, vegetables, nuts, and whole grains is recommended, though increases should be gradual to avoid bloating. Regular physical activity, such as walking, also stimulates gut motility.

If lifestyle changes prove insufficient, medical professionals may suggest laxatives or stool softeners. Natural remedies like prune juice, which contains sorbitol, a natural laxative, are also noted as effective options for managing constipation. Patients experiencing severe side effects or concerning symptoms, such as acute pancreatitis, are advised to consult a doctor.