Weight Loss Drugs: A Lifetime Sentence?

Many individuals using weight-loss medications like Wegovy and Ozempic are hesitant about long-term commitment. However, extensive research indicates that stopping these drugs almost invariably results in weight regain. A significant majority of patients, estimated by Dr. Padmaja Akkireddy to be over half of her practice, do not wish to continue these treatments indefinitely. Data reveals that most Americans cease taking these medications within a year of starting them.

Patients often cite affordability and bothersome side effects such as nausea and constipation as reasons for discontinuation. Additionally, some simply prefer not to rely on medication permanently. Dr. Michelle Hauser notes a common patient belief in being an exception to weight regain. However, recent studies, including one published this month, demonstrate that individuals typically regain their lost weight approximately 18 months after stopping the medication, as appetite and cravings resurface.

Beyond weight management, these drugs offer significant health benefits, such as reduced risks for heart issues and improved kidney and liver conditions, independent of weight loss. The World Health Organization recently advised long-term use for adults with obesity. Currently, there are no official guidelines for de-prescribing these medications, leaving doctors navigating a challenging balance between patient desires and the reality of sustained weight management.