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Why Your Body Fights Back After Weight-Loss Drugs
27 Jan
Summary
- Weight-loss jabs may lead to faster weight regain than dieting.
- The body has a 'set point' that resists lower weights.
- Ultra-processed foods and stress raise the body's weight set point.

Weight-loss jabs, while effective for initial reduction, can paradoxically cause faster weight regain than conventional methods. Patients may regain up to two-thirds of lost weight within a year of stopping the medication.
This phenomenon is linked to the body's 'set point,' an internal thermostat for fat storage. The jabs mimic hormones like GLP-1 to reduce hunger but do not alter the set point. Upon discontinuation, old hunger signals re-emerge, prompting the body to return to its previously higher set weight.
This biological response is not a matter of willpower. Repeated dieting also triggers the body's defense mechanisms, slowing metabolism and increasing hunger as it perceives famine. Ultra-processed foods, chronic stress, and poor sleep contribute to raising the set point by confusing hormonal signals.




