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Synthetic Cooling Compounds in E-Cigarettes Raise Health Concerns
23 Aug
Summary
- Scientists assess e-cigarettes with synthetic cooling compounds
- Study conducted on participants aged 18-45 in 2025
- Participants' blood pressure and heart rate measured after exposure

According to a study conducted in 2025, researchers from Yale University and Boston University have assessed the effects of e-cigarettes containing synthetic cooling compounds on a group of participants aged between 18 and 45. The study required the participants to abstain from food, caffeine, tobacco, and exercise for six hours prior to testing.
During the study, the participants took a three-to-four-second drag from the e-cigarettes every 30 seconds over a 10-minute period. Their blood pressure and heart rate were then measured 10 minutes after exposure. The findings of this research have raised concerns about the potential health implications of these new e-cigarette products that utilize synthetic cooling agents to mimic the sensation of menthol without the minty odor.
The study's results are expected to contribute to the ongoing discussions and regulations surrounding the use of e-cigarettes, particularly those with novel formulations that may have unforeseen effects on users' cardiovascular health.