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Sublocade: Strongest Shield Against Fentanyl Deaths
12 Nov
Summary
- Sublocade injection shows superior overdose protection over other therapies.
- Monthly Sublocade injection reduces fentanyl cravings and overdose risk.
- New research indicates Sublocade may prevent fentanyl-related deaths.

Encouraging news has emerged in the fight against fentanyl addiction. A London-based physician's research suggests that Sublocade, an opioid treatment administered as a once-monthly injection, offers superior protection against overdoses compared to other common therapies like methadone, Suboxone, and Kadian. This treatment was first introduced in Canada at London's Rapid Access Addiction Medicine (RAAM) Clinic in 2019.
Led by Dr. Kenneth Lee, medical director of the London RAAM Clinic, the study analyzed data from over 45,000 individuals who experienced opioid-related overdoses between 2022 and 2024. The research indicated that while other treatments still carried a risk of overdose, Sublocade provided a significant reduction in this risk. Dr. Lee stated that Sublocade's primary benefit is reducing fentanyl cravings, with the added advantage of preventing fatal overdoses.
Unlike daily medications, Sublocade's monthly injection format has been positively received by patients, alleviating anxiety about potential overdoses. While the protective effects are specific to fentanyl addiction, these findings represent a crucial advancement. The study has been published in Frontiers in Public Health, and its results are being shared at addiction medicine conferences.