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South India's Unique Heart Gene Risk Found
1 Dec
Summary
- South Indian genetic pattern raises hypertrophic cardiomyopathy risk.
- Mutations differ from Western populations, requiring tailored screening.
- Study points to MYH6 gene variations, unlike common European findings.
Researchers in Bengaluru have uncovered a distinct genetic signature among South Indians that markedly elevates their risk for hypertrophic cardiomyopathy (HCM), a serious heart condition. This finding, published in the Journal of the American Heart Association, reveals that the genetic mutations prevalent in this population differ significantly from those commonly observed in Western countries.
The study, involving a large cohort of South Indian HCM patients, identified that variants in genes like MYH6 are more common, whereas mutations in MYBPC3 and MYH7, which are frequent globally, are less so. This population-specific genetic profile challenges long-held assumptions in cardiovascular research and highlights a critical gap in understanding HCM.
These revelations are poised to revolutionize cardiac care in India, enabling more accurate diagnoses and the development of targeted screening programs. The research paves the way for personalized medicine, offering hope for improved early detection and better clinical outcomes for individuals of South Indian origin.
