HIV Pioneer's Legacy: UK's First Antibody Test Developed

Virologist Robin Weiss, a leading figure in the UK's response to the AIDS pandemic, has died at the age of 86. In 1984, Weiss led a team that identified the CD4 molecule as the cellular receptor for HIV. This pivotal discovery paved the way for establishing productive HIV growth in immortalized cell lines.

This achievement allowed for the development of the UK's first antibody test for HIV, later commercialized. The test enabled accurate, large-scale identification of individuals infected with HIV. Weiss also first demonstrated antibody neutralization of HIV, a critical basis for developing effective vaccines.

Weiss's influential career also included work on retroviruses and oncogenes. He directed the Institute of Cancer Research in London from 1980 to 1989, during which time his lab identified a novel oncogene known as N-RAS, laying groundwork for anti-cancer drug development. He returned to University College London in 1999, continuing research on retroviruses and other eclectic scientific puzzles.

Throughout his career, Weiss was a generous mentor and a prolific commentator on HIV. His contributions to virology and medicine were widely recognized, including fellowships from prestigious scientific societies. He is survived by his wife, two daughters, and grandchildren.