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Ozempic Pause: Surgery Risks Rise
20 Apr
Summary
- GLP-1 drugs slow stomach emptying, increasing aspiration risk.
- Patients taking Ozempic may need to pause medication before surgery.
- Consult doctors for personalized advice on medication timing pre-surgery.

Anesthesiologists are urging patients taking GLP-1 receptor agonists, such as Ozempic and Wegovy, to pause their medication before elective surgeries. These popular drugs, prescribed for diabetes and weight management, significantly slow gastric emptying. This effect can lead to residual stomach contents even after standard fasting, increasing the risk of aspiration pneumonia during anesthesia.
Recent studies indicate that a considerable percentage of patients on semaglutide still have undigested food in their stomachs days after taking the medication. This presents a serious safety concern for anesthesiologists, as it can lead to regurgitation and vomiting, potentially causing aspiration into the lungs. The American Society of Anesthesiologists recommends that patients consult their healthcare providers well in advance of any planned procedure.
Recommendations include pausing daily medications on the procedure day, stopping weekly injections several days prior, or undergoing an individual risk assessment. The primary goal is to ensure an empty stomach to minimize anesthetic complications. Patients must inform their doctors about all medications they are taking, including GLP-1 drugs, and strictly follow personalized instructions for medication cessation and fasting.