What is C. diff and how does it relate to opioid use?

C. diff is a colon infection that may be more common in patients taking opioids due to disruptions in gut bacteria and immune function.

Can opioids cause Clostridioides difficile infections?

Research suggests a correlation, indicating opioid users have a higher likelihood of developing C. diff infections.

Who is at higher risk for C. diff from opioids?

Hospitalized or immunocompromised patients are considered at higher risk for C. diff when taking opioids.

Home / Health / Opioid Use Linked to Dangerous C. diff Infections

Opioid Use Linked to Dangerous C. diff Infections

10 Dec, 2025

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Summary

Opioid users show a higher incidence of C. diff infections.
C. diff infection affects the colon and can spread easily.
Research suggests gut microbiome disruption by opioids.

Taking opioid medications may heighten the likelihood of developing a serious infection known as Clostridioides difficile (C. diff), new research suggests. This infection targets the colon and can spread rapidly, posing a significant risk, particularly within healthcare settings.

University of Georgia researchers analyzed data from nearly 120,000 patients, revealing that approximately 31% of those on opioids contracted C. diff, in contrast to 17% of individuals not using opioids. Experts suggest that opioids can disrupt the gut's natural bacteria balance and potentially suppress the immune system, creating conditions favorable for harmful bacteria like C. diff to thrive.

While the findings highlight potential risks, researchers stress that opioids remain a necessary treatment for many, especially for managing severe pain after surgery or injury. The decision to prescribe opioids should be individualized, considering a patient's overall health and susceptibility to infection, with greater caution advised for hospitalized or immunocompromised individuals.

Disclaimer: This story has been auto-aggregated and auto-summarised by a computer program. This story has not been edited or created by the Feedzop team.