What are the potential side effects of long-term omeprazole use?

Omeprazole, a common medication for acid reflux and stomach issues, can lead to deficiencies in essential vitamins and minerals like vitamin B12, magnesium, and calcium if taken for an extended period. This may cause fatigue, weak bones, and other health problems.

How can patients on long-term omeprazole avoid nutrient deficiencies?

Dr. Amir Khan, an NHS GP, advises patients to have their vitamin levels checked regularly and incorporate more green leafy vegetables, nuts, and dairy into their diet to maintain proper nutrient levels. Patients may also be able to reduce their dosage or use omeprazole intermittently, but should always consult their doctor first.

What other health risks are associated with long-term omeprazole use?

In addition to nutrient deficiencies, prolonged omeprazole use has been linked to an increased risk of infections like Clostridioides difficile (C. diff), as well as a higher chance of developing pneumonia and bone fractures.

Home / Health / Doctor Warns of Nutrient Deficiencies from Long-Term Omeprazole Use

Doctor Warns of Nutrient Deficiencies from Long-Term Omeprazole Use

13 Nov, 2025

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Summary

Omeprazole can lower levels of essential vitamins and minerals
Long-term use may increase risk of infections, bone fractures, and kidney problems
Patients advised to monitor vitamin levels and speak to their doctor

Doctor Warns of Nutrient Deficiencies from Long-Term Omeprazole Use

According to Dr. Amir Khan, an NHS GP and resident doctor at ITV, long-term use of the common medication omeprazole can pose significant health risks. Omeprazole, a proton pump inhibitor (PPI) typically prescribed for acid reflux, heartburn, and stomach ulcers, can lower the body's absorption of essential vitamins and minerals if taken for an extended period.

Dr. Khan cautions that prolonged omeprazole use may lead to deficiencies in vitamin B12, magnesium, and calcium. This can leave patients feeling tired and increase their risk of weaker bones and other complications. Additionally, the reduction in stomach acid from omeprazole may heighten the chances of contracting infections like Clostridioides difficile (C. diff), as well as raise the risk of pneumonia and bone fractures.