Omega Fatty Acids Could Be Key to Combating Chronic Daytime Fatigue

On September 10, 2025, sleep experts at Brigham and Women's Hospital in Boston announced a groundbreaking discovery that could redefine the understanding of excessive daytime sleepiness (EDS). The researchers have identified seven molecules in the blood that are linked to this debilitating condition, which affects up to a third of U.S. adults and increases the risk of diabetes, obesity, and heart disease.

The study, published in the journal eBioMedicine, suggests that diet and genetics play a crucial role in EDS. The researchers found that omega-3 and omega-6 fatty acids, typically found in fatty fish, egg yolks, and nuts, are associated with a lower risk of daytime drowsiness. Conversely, tyramine, a compound found in fermented and overripe foods, was linked to an increased risk of EDS, particularly in men.

"Our study suggests diet and genetics may play an important role in EDS," said Dr. Tariq Faquih, an expert in sleep disorders at Brigham and Women's Hospital. "As we learn what's happening biologically, we are beginning to understand why EDS occurs, the early signs that someone might have it, and what we can do to help patients."

The researchers also identified three additional molecules that varied by sex, with hormones like progesterone associated with sleep-related processes like melatonin production. While the study highlights potential treatment targets for EDS, including dietary changes, the researchers noted that further research is needed to confirm their findings.