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New PTSD Therapy Targets Brain's Memory Network
12 Aug
Summary
- New treatment targets brain's memory network for PTSD.
- Study shows significant reduction in intrusive memories.
- Personalized brain scans guide targeted magnetic stimulation.

Researchers have developed a novel treatment for PTSD that targets the brain's memory network, offering a new approach to managing traumatic memories. This method focuses indirectly on the hippocampus, a key area for memory formation and retrieval, by stimulating a connected surface region identified through personalized fMRI scans.
The treatment involves deliberately reactivating traumatic memories before applying transcranial magnetic stimulation (TMS). This strategy aims to leverage a temporary window of memory instability, making the memory more susceptible to change and weakening the impact of intrusive recollections.
Early findings from a proof-of-concept study indicate significant success, with intrusive memories decreasing by roughly 70% and overall PTSD symptom severity scores improving. Changes were notably seen in symptoms related to intrusive memories and arousal, suggesting a direct impact on the targeted brain network.
This innovative treatment differs from standard therapies by focusing on the memory process itself rather than solely on fear or mood. By personalizing the stimulation point based on individual brain connectivity and intervening during memory recall, the therapy shows potential for more effective and targeted PTSD treatment.