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New Triple-Action Drug Promises Major Weight Loss
12 Jan
Summary
- Triple-agonist drug targets GLP-1, GIP, and glucagon receptors.
- Retatrutide trial showed up to 28.7% weight loss in 68 weeks.
- Drug also significantly improves knee arthritis pain and function.
A new generation of weight-loss medication, informally termed 'GLP-3,' is emerging with potent effects that surpass existing GLP-1 treatments. Retatrutide, a triple-agonist developed by Eli Lilly, targets GLP-1, GIP, and glucagon receptors. This multifaceted approach has yielded significant results in clinical trials. For example, a phase 3 trial concluded in December, showing participants with obesity and knee arthritis lost an average of 71.8 lbs (28.7%) over 68 weeks.
Beyond its impact on weight, retatrutide demonstrates substantial benefits for related health issues. The same trial reported a 75.8% average reduction in knee arthritis pain scores, indicating significant improvements in comfort and mobility. These findings suggest that retatrutide could offer a dual benefit for individuals struggling with both obesity and associated joint pain and dysfunction.
With seven additional phase 3 trials expected to conclude in 2026, retatrutide could potentially receive FDA approval in 2027, marking a new milestone in obesity treatment. While gastrointestinal issues are common side effects, similar to GLP-1 drugs, its broader metabolic benefits may extend to conditions like type 2 diabetes and cardiovascular risk reduction.
