What rare genetic condition caused Molly's death?

Molly died from PPA2, identified as a rare genetic mitochondrial condition.

How is PPA2 passed on?

PPA2 is a genetic condition that is passed down from parents who are carriers of the problem.

Which organization helped Melissa Mae Carlton's family?

The organization Sudden Unexplained Death in Childhood (SUDC) provided support and genetic testing assistance.

Home / Health / Mom Reveals Daughter's Rare Genetic Killer

Mom Reveals Daughter's Rare Genetic Killer

24 Apr

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Summary

Rare genetic mitochondrial condition identified as cause of death.
Condition, PPA2, is passed down from carriers and affects mitochondria.
Organization SUDC provided support and aided in genetic testing.

Mom Reveals Daughter's Rare Genetic Killer

Melissa Mae Carlton recently shared the diagnosis of her late daughter, Molly, who passed away in December 2025. Four months after her child's death, Carlton revealed on Instagram that Molly suffered from PPA2, a rare genetic mitochondrial condition. This condition is inherited from parents who carry the gene and can affect the heart if mitochondria are compromised.

Carlton expressed relief that her family has found closure, identifying PPA2 as the likely cause of death for both Molly and her second daughter, Abigail, who died in 2024 from sepsis. She highlighted that many doctors are not fully aware of PPA2, emphasizing the need for increased awareness. Her family is undergoing tests to ensure no one else is affected.