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Hidden Heart Risk: What Your Cholesterol Test Misses
3 Nov
Summary
- Lipoprotein(a) (Lp(a)) is an inherited heart disease risk.
- Standard cholesterol tests do not measure Lp(a) levels.
- About 1 in 5 people worldwide have elevated Lp(a) levels.

Newer medical guidelines are emphasizing the importance of testing for lipoprotein(a), or Lp(a), a genetic factor that significantly elevates heart disease risk. Unlike LDL cholesterol, Lp(a) levels are largely determined by inherited traits, meaning healthy lifestyle choices may not adequately mitigate this specific risk. Approximately 20% of the global population has elevated Lp(a).
This key marker is not included in standard cholesterol panels, necessitating a separate blood test. Doctors recommend adults undergo this test at least once. High Lp(a) levels are associated with plaque buildup in arteries, increasing the likelihood of heart attack and stroke. Elevated levels are also linked to aortic stenosis, a narrowing of the heart's main valve.
If an Lp(a) test reveals higher-than-normal levels, it's crucial to consult with a healthcare provider. While statins don't directly lower Lp(a), they reduce LDL cholesterol, contributing to overall risk reduction. Further assessment may involve considering other risk factors like blood pressure, family history, and diabetes. Specialized treatments like lipoprotein apheresis exist but are reserved for a small patient group.