What is LIT therapy for infertility?

LIT therapy involves injecting processed samples of one partner's blood into the other to help the immune system build tolerance.

Can a woman's immune system reject her husband's DNA?

Yes, in rare cases, a woman's immune system can identify her partner's DNA as foreign and attack it, leading to infertility.

What are signs of unexplained infertility?

Unexplained infertility occurs when standard medical tests show no clear cause for inability to conceive after a year of trying.

Home / Health / Couple's Immune System Attacked Husband's DNA

Couple's Immune System Attacked Husband's DNA

12 Jan

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Summary

A genetic predisposition caused the wife's immune system to attack the husband's DNA.
The couple pursued LIT therapy, an immunotherapy to build immune tolerance.
Openly sharing their fertility struggles aims to help other couples feel less alone.

Couple's Immune System Attacked Husband's DNA

Alex and Paul Klein discovered a unique biological challenge two years into their marriage: Alex's immune system was incompatible with Paul's DNA, preventing conception. After unexplained infertility and unsuccessful IVF rounds, at-home blood tests revealed Alex's body viewed Paul's DNA as foreign, triggering an immune response. This diagnosis, though emotionally challenging, provided clarity and paved the way for specialized treatment.

The couple began Lymphocyte Immunotherapy (LIT), a process involving injecting processed samples of Paul's blood into Alex. This treatment aims to retrain Alex's immune system to accept Paul's genetic material. Alongside other immune-regulating therapies, Alex was several months into the six-month treatment plan when sharing her story.