What two gut bacteria trigger chronic constipation?

Akkermansia muciniphila and Bacteroides thetaiotaomicron have been identified as the two gut bacteria that trigger chronic constipation by degrading the colon's protective mucus layer.

Why do laxatives often fail for chronic constipation?

Laxatives often fail because chronic constipation can be caused by the loss of protective colon mucin, making stool dry and hard, rather than slow gut motility.

How can constipation be treated based on this new research?

New treatments may focus on protecting the colon's mucus barriers, potentially by using medicines that block the sulfatase enzyme, rather than solely on stimulating gut movement.

Home / Health / Gut Bacteria Ruin Colon Mucus, Cause Constipation

Gut Bacteria Ruin Colon Mucus, Cause Constipation

21 Feb

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Summary

Two gut bacteria break down protective colon mucus.
Mucin loss causes dry stool, explaining laxative failure.
This finding impacts chronic constipation and Parkinson's.

Gut Bacteria Ruin Colon Mucus, Cause Constipation

Scientists have pinpointed two specific gut bacteria, Akkermansia muciniphila and Bacteroides thetaiotaomicron, as triggers for chronic constipation. These microbes work sequentially to degrade the colon's protective mucus lining, a crucial barrier that maintains stool moisture and facilitates passage.

This degradation process leaves stool dry and hard, offering a scientific explanation for why common treatments like laxatives frequently fail. The findings are particularly relevant for individuals with treatment-resistant constipation, including those with Parkinson's disease, where constipation can precede motor symptoms by decades.