What happens to weight after stopping GLP-1 medications?

After stopping GLP-1 medications, individuals typically regain lost weight within about 1.5 years, often at a rate four times faster than with lifestyle interventions.

What is the best approach for using GLP-1 obesity medications?

Combining GLP-1 medications with comprehensive lifestyle changes offers the maximum long-term benefit for patients.

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GLP-1 Drugs: Weight Regain Risks Revealed

Q: Why does the body regain weight after stopping GLP-1s?

Metabolic adaptation, a biological survival mechanism, causes the body to slow metabolism and conserve energy when weight is lost, leading to increased appetite after stopping GLP-1s.

28 Jan

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Summary

Weight regain is common within 1.5 years after stopping GLP-1s.
Metabolic adaptation explains why the body seeks to regain weight.
Combining drugs with lifestyle changes offers best results.

GLP-1 Drugs: Weight Regain Risks Revealed

Obesity doctors and researchers express concern over the marketing of GLP-1 drugs as mere lifestyle fixes. These medications, designed for chronic conditions like obesity and Type 2 diabetes, are often discontinued within a year by nearly half of users.

Studies reveal a significant trend: after cessation, individuals typically regain lost weight within about 1.5 years. This weight regain occurs at a rate four times faster than with lifestyle interventions. Health improvements seen while on the medication, such as better blood sugar and blood pressure, also revert to baseline.

Experts explain that metabolic adaptation, a biological survival mechanism, causes the body to slow metabolism and conserve energy when weight is lost. When GLP-1s are stopped, this heightened appetite can lead to overeating. Doctors stress that for optimal outcomes, these therapies must be integrated with comprehensive lifestyle changes.