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TGA Warns on Diabetes Drug Side Effects
1 Dec
Summary
- Mental health warnings issued for GLP-1 agonists.
- Contraception effectiveness may be reduced by Mounjaro.
- Suicidal thoughts are a potential side effect to monitor.

The Therapeutic Goods Administration (TGA) has introduced critical safety alerts concerning widely used GLP-1 receptor agonist medications, including Ozempic, Wegovy, Saxenda, Trulicity, and Mounjaro. These drugs, primarily prescribed for diabetes and weight management, are now flagged for potential mental health side effects.
Doctors are advised by the TGA to closely monitor patients for any signs of depression, suicidal ideation, or unusual behavioral changes. This proactive measure addresses reported instances of suicidal behavior and ideation associated with this class of drugs, emphasizing the need for careful patient observation.
Furthermore, the TGA issued a specific warning regarding Mounjaro and its impact on contraception. A potential for reduced effectiveness of oral contraceptives has been identified when initiating or increasing Mounjaro dosage. Patients using oral contraceptives are now advised to use non-oral methods or barrier contraception for a period after starting or adjusting Mounjaro.




