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CFS: Immune System & Blood Vessels Off-Balance
17 Dec, 2025
Summary
- Chronic fatigue syndrome shows disruptions in vascular and immune system balance.
- White blood cells in CFS patients exhibit reduced energy generation.
- Abnormalities found across multiple biological systems in CFS patients.
Recent scientific analysis of blood proteins from individuals with chronic fatigue syndrome (CFS) has uncovered evidence of dysregulation in both the vascular and immune systems. The study, published in Cell Reports Medicine, identifies simultaneous abnormalities across various biological systems in CFS patients, underscoring the condition's inherent complexity.
Researchers noted a significant "energy stress" within white blood cells, characterized by increased levels of adenosine monophosphate (AMP) and adenosine diphosphate (ADP), signaling a diminished capacity to produce adenosine triphosphate (ATP), the primary energy currency of cells. This reduction impacts essential cellular functions.
Furthermore, the investigation revealed a trend towards less mature immune cells, including T-lymphocytes, dendritic cells, and natural killer cells, among those with CFS. Simultaneously, elevated levels of proteins associated with blood vessel lining activation and remodeling were detected, alongside lower levels of immunoglobulin-related proteins, collectively pointing to a disruption of vascular and immune homeostasis.
