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New Gene Tests Unlock Hidden Cancer Risks Years Later
13 Oct
Summary
- Older cancer gene tests focused only on BRCA1 and BRCA2.
- Advancements mean newer tests screen dozens of genes.
- Retesting is recommended for those with prior negative results and family history.
Women who underwent genetic testing for inherited cancer risk in the past may benefit from retesting, according to current medical recommendations. Gene testing technology has advanced considerably since initial tests focused on only BRCA1 and BRCA2 genes. These early tests, which began in 1996, provided an incomplete view of inherited cancer predispositions.
Following the 2013 Supreme Court decision to strike patents on BRCA genes, broader 'panel' tests emerged, analyzing dozens of genes simultaneously. Medical professionals estimate that thousands of individuals may need to be retested to gain a more comprehensive understanding of their genetic risk factors. This updated testing is crucial for informing preventative measures like medication or prophylactic surgery.
However, retesting is not universally necessary. The National Cancer Institute advises that repeating the exact same test is generally not beneficial. Updated testing is most valuable when an earlier negative result contrasts with a significant family history of cancer or when a new cancer diagnosis occurs that the initial test did not cover. Potential hurdles include insurance coverage and the possibility of encountering 'variants of uncertain significance'.
