Berberine vs. Ozempic: Experts Debunk 'Natural' Weight Loss

Berberine, a plant-derived supplement available without a prescription, is gaining popularity as a natural alternative to weight loss drugs like Ozempic and Wegovy. While it can improve insulin sensitivity and modestly aid in weight loss by activating the AMPK enzyme, experts emphasize its effects are far less potent than prescription GLP-1 agonists. These powerful medications primarily suppress appetite, leading to significant weight reduction.

Medical professionals express concern that berberine's widespread promotion on social media creates unrealistic expectations. They warn that individuals may delay evidence-based obesity treatments, such as medication or surgery, in favor of supplements like berberine. This delay can result in a worsening of their health condition, as berberine's metabolic effects are considerably milder than those of prescription drugs.

Furthermore, berberine, classified as a dietary supplement, bypasses rigorous FDA safety and efficacy testing, raising concerns about purity and potential interactions with other medications. Experts advise caution, noting potential gastrointestinal side effects and the risk of dangerously amplifying the effects of diabetes medications. They recommend prioritizing lifestyle changes, including increased fiber intake, reduced processed foods, resistance training, and adequate sleep, as the most reliable path to weight management.