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Beige Fat Loss Linked to Skyrocketing Blood Pressure
16 Jan
Summary
- Low beige fat levels increase blood pressure sensitivity, raising heart risks.
- Beige fat helps burn energy and directly influences blood pressure control.
- Findings in mice show mutations linked to beige fat loss correlate with human hypertension.
Researchers have elucidated the crucial role of beige fat in regulating blood pressure, a discovery that sheds new light on hypertension.
Studies involving genetically altered mice revealed that a deficiency in beige fat, which aids in energy expenditure and thermogenesis, leads to increased blood vessel sensitivity to pressure signals. This heightened sensitivity, linked to the production of angiotensinogen, drives up blood pressure and can initiate fibrotic changes in blood vessels.
These findings in mice have significant implications for human health, as mutations in the PDM16 gene, associated with beige fat loss, have been observed in individuals with higher blood pressure. The research, published in Science, suggests that the type of fat surrounding blood vessels plays a critical role in cardiovascular function and opens avenues for developing personalized hypertension treatments.
