Can sertraline reduce violence according to the UNSW trial?

The UNSW trial found sertraline significantly reduced domestic violence reoffending, particularly when combined with psychosocial support.

How effective was the new domestic violence intervention in Australia?

The intervention reduced repeated domestic violence offending by 44% and significantly improved partner safety.

What is the cost-effectiveness of the sertraline domestic violence program?

The program is considerably more cost-effective than incarceration, costing about A$7,000 per participant annually.

Home / Health / Can Antidepressants Stop Domestic Violence?

Can Antidepressants Stop Domestic Violence?

2 Dec, 2025

•

Summary

Sertraline reduced domestic violence reoffending by 30%.
Trial included comprehensive psychosocial support for participants.
96% of partners reported maintained or increased safety.

Can Antidepressants Stop Domestic Violence?

A world-first trial by the University of New South Wales and University of Newcastle investigated whether the antidepressant sertraline could decrease domestic violence reoffending in impulsive men. The study, involving 630 participants, found that consistent use of sertraline was linked to a 30% reduction in domestic violence reoffending over 24 months.

Beyond medication, the trial incorporated a comprehensive support model. This included trauma-informed counselling, proactive follow-ups, and assistance with navigating social services. This holistic approach proved crucial for participant engagement and improved outcomes.

The intervention demonstrated significant success, with a 44% reduction in repeated domestic violence offending compared to placebo. Furthermore, 96% of partners reported maintained or increased safety, indicating a substantial positive impact on those affected by domestic violence.