What is Cushing's syndrome, and how did it affect Amy Schumer?

Cushing's syndrome is a hormonal disorder caused by prolonged high cortisol levels, leading to symptoms like puffiness and fatigue, which affected Amy Schumer.

Why did Amy Schumer lose 50 pounds?

Amy Schumer lost 50 pounds to survive Cushing's syndrome, a serious condition that caused significant health issues, not for cosmetic reasons.

What are the symptoms of Cushing's syndrome?

Symptoms include extreme swelling (especially facial puffiness), fatigue, weight gain in specific areas, thinning skin, high blood pressure, and potentially fatal complications.

Home / Health / Amy Schumer's Secret Health Battle: Cushing's Revealed

Amy Schumer's Secret Health Battle: Cushing's Revealed

13 Dec, 2025

•

Summary

Amy Schumer lost 50 pounds due to Cushing's syndrome, not for appearance.
Cushing's syndrome involves high cortisol levels, causing puffiness and potentially fatal complications.
Treatment focuses on normalizing cortisol, with weight loss medication as an adjunct.

Amy Schumer's Secret Health Battle: Cushing's Revealed

Comedian Amy Schumer has disclosed her battle with Cushing's syndrome, a serious hormonal disorder that prompted her significant weight loss. The 44-year-old actress clarified that her 50-pound weight reduction was essential for survival, not aesthetics, as the condition can lead to life-threatening complications if untreated. She shared that she is now pain-free and more active with her son.

Cushing's syndrome is characterized by prolonged exposure to high levels of the stress hormone cortisol, often due to steroid use. This excess cortisol can cause a distinctive redistribution of body fat, leading to facial puffiness, abdominal fat, and a "buffalo hump." Other symptoms include thinning limbs, high blood pressure, bone loss, and skin issues.