What is Christina Applegate's current battle with multiple sclerosis?

Christina Applegate has been open about her ongoing struggle with multiple sclerosis (MS), a chronic and often debilitating condition. She has revealed how stress can trigger severe flare-ups, causing her to fall repeatedly and leaving her legs "busted."

How has Christina Applegate's MS affected her daily life?

Applegate has described her daily reality with MS as "living in hell," citing the loneliness and intense physical pain she experiences. She has also been hospitalized over 30 times in the past 3 years due to MS-related issues like vomiting, diarrhea, and severe discomfort.

Why is Christina Applegate's openness about her MS journey important?

Applegate's decision to be "real, raw, and honest" about her MS on social media, after years of keeping much of her struggle private, is a powerful act of vulnerability. Her candid sharing helps raise awareness and understanding about the realities of living with chronic illnesses.

Home / Health / Actress Christina Applegate Bravely Shares MS Struggles

Actress Christina Applegate Bravely Shares MS Struggles

17 Nov

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Summary

Applegate reveals how stress worsens her MS symptoms
She has fallen 5 times in the past few days due to leg weakness
Applegate has been hospitalized over 30 times in 3 years for MS-related issues

Actress Christina Applegate Bravely Shares MS Struggles

On November 17, 2025, beloved actress Christina Applegate, known for her roles in Dead to Me and Married... with Children, shared a vulnerable and powerful Instagram post about her ongoing battle with multiple sclerosis (MS). Applegate, who was diagnosed with the disease in 2021, has been open about the physical and mental toll it has taken on her life.

In her recent post, Applegate candidly revealed how stress and unexpected events can exacerbate her MS symptoms. She explained that just a few days prior, she had experienced a flare-up that caused her to fall five times, leaving her legs "busted." Applegate emphasized the importance of understanding the challenges faced by those living with chronic illnesses like MS, where even minor stressors can have a significant impact.

Applegate's honesty extends beyond her recent Instagram post. In interviews, she has described her daily reality as "living in hell," citing the loneliness and pain that come with her condition. The actress has also been hospitalized more than 30 times over the past three years due to severe symptoms, including vomiting, diarrhea, and intense physical discomfort.