Actress Christina Applegate Bravely Shares MS Struggles

On November 17, 2025, beloved actress Christina Applegate, known for her roles in Dead to Me and Married... with Children, shared a vulnerable and powerful Instagram post about her ongoing battle with multiple sclerosis (MS). Applegate, who was diagnosed with the disease in 2021, has been open about the physical and mental toll it has taken on her life.

In her recent post, Applegate candidly revealed how stress and unexpected events can exacerbate her MS symptoms. She explained that just a few days prior, she had experienced a flare-up that caused her to fall five times, leaving her legs "busted." Applegate emphasized the importance of understanding the challenges faced by those living with chronic illnesses like MS, where even minor stressors can have a significant impact.

Applegate's honesty extends beyond her recent Instagram post. In interviews, she has described her daily reality as "living in hell," citing the loneliness and pain that come with her condition. The actress has also been hospitalized more than 30 times over the past three years due to severe symptoms, including vomiting, diarrhea, and intense physical discomfort.

Despite the immense challenges, Applegate remains determined to share her story and raise awareness about the realities of living with MS. Her decision to be "real, raw, and honest" on social media, after years of keeping much of her struggle private, is a powerful testament to her strength and resilience.