Sister Act: Van Patten Sisters Shine in Knox True Crime Drama

The acting talents of sisters Grace and Anna Van Patten are showcased in the limited series 'The Twisted Tale of Amanda Knox.' Grace Van Patten takes on the lead role of Amanda Knox, portraying the period following Knox's wrongful accusation in Meredith Kercher's murder trial, her incarceration, and subsequent release. Anna Van Patten appears in the series as Knox's real-life sister, Deanna.

This project marks the sisters' first on-screen collaboration, having previously grown up in New York City and attended Fiorello H. LaGuardia High School. Their father, Timothy Van Patten, is a notable director and producer, further cementing the family's presence in the entertainment industry. Grace Van Patten's prior notable roles include appearances in 'Boardwalk Empire,' 'Maniac,' and 'Nine Perfect Strangers,' and she gained significant recognition for her role in Hulu's 'Tell Me Lies.'

Anna Van Patten has also been building her acting resume with appearances on shows like 'Law & Order: Special Victims Unit,' 'FBI: Most Wanted,' and 'Gossip Girl.' She is also set to feature in the upcoming season 3 of 'Euphoria,' where she plays Kitty, a newcomer at a strip club.

The series, which premiered in August 2025, delves into the details of Knox's high-profile legal battle. Amanda Knox herself has expressed privilege and gratitude for being an executive producer on the show, allowing her a unique perspective on her own story's portrayal.