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Scrubs Revival Shocker: Cox Battles Rare Autoimmune Disease
9 Apr
Summary
- Dr. Perry Cox collapses and is diagnosed with a rare autoimmune disease.
- The condition, microscopic polyangiitis, causes his body to attack itself.
- J.D. promises to keep his mentor alive and prevent cynicism.

In a shocking turn during the 'Scrubs' revival, Dr. Perry Cox, a respected former chief of medicine, collapses at Sacred Heart's nurses' station. He is subsequently diagnosed with microscopic polyangiitis, a rare autoimmune disease characterized by severe vasculitis, which can lead to rapid multi-organ failure.
Despite the grim diagnosis, J.D. attempts to offer hope, explaining that aggressive treatment can potentially stave off renal failure and even lead to remission. Dr. Cox, however, grapples with the reality of his body attacking itself, questioning the possibility of karmic immunity for those who dedicate their lives to healing others.
Cox makes J.D. promise to keep him alive for a long time, fearing his death might foster cynicism. J.D. assures him of a plan and emphasizes that his mentor now needs him, signifying a shift in their relationship as J.D. takes on a more protective role.
John C. McGinley, who plays Dr. Cox, is confirmed to return for the season finale alongside other legacy cast members, including Christa Miller, Judy Reyes, and Neil Flynn. McGinley recently discussed the implications of Cox's diagnosis and the character's future.