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Manganiello's Death Scare: A Seven-Year Health Nightmare
16 Oct
Summary
- Actor Joe Manganiello faced a seven-year undiagnosed autoimmune illness.
- He nearly died from a ruptured large intestine in 2016.
- Manganiello lost 60 pounds and battled multiple skin conditions.
Actor Joe Manganiello has disclosed a severe, seven-year health crisis stemming from an undiagnosed autoimmune illness that profoundly altered his life and brought him to the brink of death. In October 2026, his memoir, Bloodlines, detailed these experiences.
In 2016, Manganiello collapsed on a film set in Wilmington, North Carolina, and underwent emergency surgery to remove his entire large intestine due to a rupture. This procedure necessitated the use of an ostomy bag, a challenging reality he recounts in his book.
During this period, Manganiello endured chronic pain and a significant 60-pound weight loss. His health issues also manifested as multiple severe skin conditions, which he attributed to his compromised immune system. Despite the prolonged fight for survival, doctors had few definitive answers for his cascade of symptoms.
As of October 2026, Manganiello reports being symptom-free and no longer requires medication, marking the conclusion of this arduous chapter. He also touches upon his marriage to Sofía Vergara, noting the emotional distance that developed during his illness.
