Grey's Anatomy Couple Reunites, Sparking Spin-off Rumors

In May 2022, Grey's Anatomy fans were treated to a surprise reunion of the show's beloved couple, Jackson and April, played by Jesse Williams and Sarah Drew. The pair, who had both exited the long-running medical drama in recent years, returned to Seattle for the series' 400th episode, where viewers were delighted to see the characters reunited and even sharing a sweet kiss.

The unexpected reunion has sparked renewed interest in the Japril storyline, with both actors hinting that the door may still be open for more content featuring their characters. Sarah Drew, who portrayed April, told Deadline in May 2022 that the episode's ending left "a lot of open-ended questions" about the couple's future, and that she had received inquiries from the Grey's Anatomy cast and crew about the possibility of her returning next year.

While no official plans for a Japril-focused spin-off have been announced, the actors' comments suggest that the idea is at least being considered. Fans of the couple have long been vocal about their desire to see more of Jackson and April's story, and the enthusiastic response to their recent reunion may be enough to convince the Grey's Anatomy team to explore the possibility further.

As of October 2025, the future of the Japril storyline remains uncertain, but the enduring popularity of the characters and the continued interest from both the cast and the audience indicate that there may be more in store for this beloved couple.