What happens in Family Guy's 450th episode, 'The Edible Arrangement'?

In the 450th episode, Lois and Stewie Griffin communicate for the first time, with their conversation prompted by edible gummies and leading to therapeutic discussions.

Why is the 450th episode of Family Guy considered significant?

It's significant because it marks the first time Lois and Stewie Griffin have a direct conversation after 23 seasons, offering a therapeutic exploration of their relationship.

Will there be more episodes focusing on Stewie and Lois after the 450th?

Yes, the success of their interaction in the 450th episode has inspired the writing team to consider and potentially develop future adventures for the Stewie and Lois duo.

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Lois & Stewie Connect: A 'Family Guy' Milestone

15 Feb

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Summary

Lois and Stewie communicate for the first time in season 24.
Gummies from a new dispensary trigger therapeutic conversations.
The 450th episode has inspired future adventures for the duo.

Lois & Stewie Connect: A 'Family Guy' Milestone

The 450th episode of "Family Guy," titled "The Edible Arrangement," features a groundbreaking interaction between Lois and Stewie Griffin. For the first time in the show's 23 seasons, the mother and son engage in direct communication, facilitated by edible gummies obtained from a newly opened legal dispensary in Quahog.

This unprecedented dialogue proves to be remarkably therapeutic for both characters, offering a unique glimpse into their complex relationship. Alex Borstein, the voice of Lois Griffin, expressed that this episode is among her favorites due to its humorous yet profound exploration of the mother-son dynamic. The experience was so impactful that it has spurred the show's writing team to consider developing further storylines centered on Stewie and Lois.

The milestone episode also highlighted a memorable live table read at PaleyFest for the show's 25th anniversary. Borstein performed alongside series creator Seth MacFarlane, who voices Stewie, creating a powerful moment of artistic collaboration. This 450th installment airs on February 15, 2026, at 9:30 pm ET on Fox, promising new adventures for the iconic duo.

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