Celebrities Reveal Ups and Downs of GLP-1 Medication for Weight Loss

As of October 30th, 2025, several high-profile celebrities have been opening up about their weight loss journeys involving GLP-1 medications like Ozempic and Mounjaro. Reality star Dolores Catania faced a setback when Mounjaro stopped working for her, leading to a 20-pound gain as she searched for the right wellness solution.

On a more positive note, actress Amanda Bynes is hopeful that Ozempic will help her shed over 40 pounds, and she has been sharing updates on her progress. Meanwhile, actor Sacha Baron Cohen credits a combination of Ozempic, private chefs, and personal training for his stunning physical transformation ahead of a new movie role.

The conversation around these medications, however, is not without controversy. Plastic surgeon Dr. Terry Dubrow has been vocal about the safety of such treatments, controversially comparing them to Tylenol. Tennis legend Serena Williams, on the other hand, celebrates a 31-pound weight loss, thanking the GLP-1 medication for helping her feel healthier and more energetic post-pregnancy. Model Chrissy Teigen also shared her emotional journey with Ozempic following a tragic pregnancy loss, describing how the drug helped her both physically and mentally.

Lastly, reality star Whitney Leavitt of The Secret Lives of Mormon Wives has clarified that she is no longer using Ozempic, focusing instead on other health strategies, including counting macros and exercise, after experiencing unwelcome side effects from the injections previously.