When did Jesse Williams leave 'Grey's Anatomy'?

In May 2021, Jesse Williams, who played the role of Dr. Jackson Avery, made his departure from the long-running medical drama Grey's Anatomy.

What happened to the character of April Kepner on 'Grey's Anatomy'?

The character of April Kepner, played by Sarah Drew, was let go from the show in 2018 after nine seasons. The then-showrunner Krista Vernoff explained that the writers felt April had been through so much and had come out the other side, and they didn't know what else they could put the character through.

How did the 'Grey's Anatomy' writers handle Jesse Williams' exit?

According to the actor, he was directly involved in the dialogue and the storyline surrounding his departure, which allowed him to help create a fitting end for his character, Dr. Jackson Avery.

Home / Arts and Entertainment / Grey's Anatomy Welcomes Back Fan-Favorite Actor in Surprise Comeback

Grey's Anatomy Welcomes Back Fan-Favorite Actor in Surprise Comeback

24 Oct, 2025

•

Summary

Jesse Williams reprising role of Dr. Jackson Avery on Grey's Anatomy
Possible baby on the way for Jo and Link
Characters of April and Arizona permanently woven into the show

Grey's Anatomy Welcomes Back Fan-Favorite Actor in Surprise Comeback

As of October 2025, the hit medical drama Grey's Anatomy is set to welcome back a familiar face - Jesse Williams as Dr. Jackson Avery. This comes after a major character death and some cast hiatuses on the show.

The return of Williams' character was confirmed in a recent trailer, which also teased a possible pregnancy for Jo (Camilla Luddington) and her husband, Link (Chris Carmack). While the couple is unsure about Jo's condition, the sneak peek has left fans eagerly anticipating the upcoming developments.

Williams, who played Jackson for over a decade, previously reprised the role in season 21 alongside his on-screen love interest, Sarah Drew as Dr. April Kepner. The characters of April and Arizona Robbins, played by Jessica Capshaw, were praised for being "permanently woven into the fabric of Grey's Anatomy" by the show's former showrunner Krista Vernoff.