Amy Schumer Embraces Wellness Journey with Weight Loss Medication

Comedian Amy Schumer, 44, is starting a new chapter in her life after recent weight loss. As of November 12, 2025, Schumer has been open about her experience with the FDA-approved weight loss drug Mounjaro, which she began using earlier this year.

In a recent Instagram post, Schumer shared that she is "feeling good and happy" and has even deleted her old Instagram photos for a fresh start. The Trainwreck star previously opened up about her struggles with weight loss medications, including Wegovy, which caused her to experience severe nausea and fatigue.

However, Schumer's experience with Mounjaro has been much more positive. She has reported having more energy, fuller hair, and better skin, as well as improvements in her sex drive. Schumer has also been candid about her journey with perimenopause and the benefits of taking estrogen and progesterone.

Other celebrities, such as Scott Disick, Whoopi Goldberg, and Jim Gaffigan, have also used Mounjaro for weight loss. Gaffigan, 59, recently shared that while he was initially "paranoid" about potential side effects, the medication has "kind of worked" for him.

As Schumer continues her wellness journey, she hopes to inspire her fans and destigmatize the use of weight loss medications. Her openness about her experiences serves as a reminder that everyone's journey is unique, and that seeking support and medical guidance can be a valuable step towards achieving one's health goals.